The COPa knowledgebase is configured for cardiovascular investigators. This project is developed under NHLBI Proteomics Centers consortium with the partnership among European Bioinformatics Institute (EBI), Royal Institute of Technology (KTH), The Scripps Research Institute (TSRI), Zhejiang University (ZJU), Beijing Genomics Institute (BGI), and University of California, Los Angeles (UCLA).

The objective of this project is to facilitate the advancement of cardiovascular biology and medicine by providing curated proteome knowledge. This utility is enabled by specialized bioinformatics tools and web portals. In this knowledgebase, orthogonal sets of proteomic knowledge are integrated on a signal web server, including mass spectral features, expression imaging, genetic signatures and clinical attributes. A spectral library search engine and the knowledgebase coordinate the systemic revelation of properties on cardiac proteome biology. Therefore, data-driven analyses and hypothesis-driven studies intersect to aid novel discoveries.

A comprehensive delineation of cardiac proteome dynamics is beyond the capacity of individual investigators. Therefore, collaborative efforts are necessary. COPaKB can serve these endeavors at multiple levels. (i) Results of previous studies are integrated to guide future analyses. (ii) Results from multiple ongoing analyses can be combined in real time to test new hypothesis. (iii) COPaKB Wiki component assists investigators with diverse expertise to join the knowledge-building process.